Informal Chat Session at #CCR17
Welcome to the 249th Critical Care Reviews Newsletter, bringing you the best critical care research and open access articles from across the medical literature over the past seven days. This week's highlights include two randomised controlled trials, the pilot POP-UP trial comparing PPI stress ulcer prophylaxis with placebo, and a second trial, comparing terlipressin with noradrenaline in patients with cirrhosis and septic shock. There are also observational studies on recovery after acute kidney injury, readmissions to intensive care and chloride content of resuscitation fluids, as well as interesting review articles on point-of-care coagulation management algorithms during ECMO, red blood cell transfusion strategies in critically ill patients and prehospital control of life-threatening truncal and junctional haemorrhage. If you only have time for one review article this week, try this paper on advanced hemodynamic management in patients with septic shock
If you haven't yet attended the Critical Care Reviews Meeting, then you're probably not aware of the best session of the day - the Informal Chat. After the formal talks and panel discussions have concluded, everyone gets a drink and moves towards the bar area, where an enormous meandering hour-long discussion takes place between the speakers and delegates. It's incredibly popular, as you might imagine, and unique to the Critical Care Reviews Meeting.
The talks from the 1st World Sepsis Congress will be placed online over the next few weeks. Sign up here to receive notifications of their release
- Abstract: Selvanderan. Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study. Crit Care Med 2016;44(10):1842-1850
- Abstract: Mocco. Aspiration Thrombectomy After Intravenous Alteplase Versus Intravenous Alteplase Alone. Stroke. 2016 Sep;47(9):2331-8
- Abstract: Choudhury. A randomized trial comparing terlipressin and noradrenaline in patients with cirrhosis and septic shock. Liver Int 2016;epublished September 16th
- Abstract: Sheth. Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurology 2016;15(11):1160-1169
- Abstract: Bracard. Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial. Lancet Neurology 2016;15(11):1138-1147
- Abstract: Fujikura. Adjunctive Corticosteroids for Pneumocystis jirovecii Pneumonia in Non-HIV-infected Patients: A Systematic Review and Meta-analysis of Observational Studies. Arch Bronconeumol 2016;epublished September 9th
- Abstract: Sandroni. Acute kidney injury after cardiac arrest: a systematic review and meta-analysis of clinical studies. Minerva Anestesiologica 2016;82(9):989-99
- Abstract: Arvaniti. Cumulative Evidence of Randomized Controlled and Observational Studies on Catheter-Related Infection Risk of Central Venous Catheter Insertion Site in ICU Patients: A Pairwise and Network Meta-Analysis. Crit Care Med 2016;epublished September 14th
- Abstract: Dettmer. Prognostic Factors for Long-Term Mortality in Critically Ill Patients Treated With Prolonged Mechanical Ventilation: A Systematic Review. Crit Care Med 2016;epublished September 9th
- Full Text: Quinn. Systematic review of statins in sepsis: There is no evidence of dose response. Indian J Crit Care Med 2016;20:534-41
- Abstract: Kellum. Recovery After Acute Kidney Injury. Am J Respir Crit Care Med 2016;epublished September 16th
- Full Text: Chousterman. Impact of Resident Rotations on Critically Ill Patient Outcomes: Results of a French Multicenter Observational Study. PLoS One 2016;11(9):e0162552
- Abstract: Gupta. Culture Negative Severe Sepsis – Nationwide Trends and Outcomes. Chest 2016;epublished September 15th
- Abstract: Santamaria. Readmissions to Intensive Care: A Prospective Multicenter Study in Australia and New Zealand. Crit Care Med 2016;epublished September 13th
- Abstract: Suarez. Human Albumin Use in Adults in U.S. Academic Medical Centers. Crit Care Med 2016 September 14th
- Abstract: Seitz. Evaluation of RBC Transfusion Practice in Adult ICUs and the Effect of Restrictive Transfusion Protocols on Routine Care. Crit Care Med 2016;epublished September 14th
- Full Text: Luethi. Prevalence of ketosis, ketonuria, and ketoacidosis during liberal glycemic control in critically ill patients with diabetes: an observational study. Critical Care 2016;20:297
- Abstract: Sen. Chloride Content of Fluids Used for Large-Volume Resuscitation Is Associated With Reduced Survival. Crit Care Med 2016;epublished September 15th
- Bolliger. Point-of-care coagulation management algorithms during ECMO support: are we there yet? Minerva Anestesiologica 2016;82(9):1000-9
- Xu. Mass Spectrometry-based Proteomics in Acute Respiratory Distress Syndrome: A Powerful Modality for Pulmonary Precision Medicine. Chin Med J 2016;129:2357-64
- Toniutto. Current challenges and future directions for liver transplantation. Liver Int 2016;epublished September 16th
- Paal. Accidental hypothermia–an update. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2016;24:111
- Barrera-Chimal. Mineralocorticoid Receptor Antagonism: A Promising Therapeutic Approach to Treat Ischemic AKI. Nephron 2016;134:10-13
- Selby. International Criteria for Acute Kidney Injury: Advantages and Remaining Challenges. PLoS Med 2016;13(9):e1002122
- Lelubre. Red blood cell transfusion strategies in critically ill patients: lessons from recent randomized clinical studies. Minerva Anestesiologica 2016;82(9):1010-6
- Saugel. Advanced Hemodynamic Management in Patients with Septic Shock. BioMed Research International 2016;2016:8268569
- Johannesen. Lemierre’s syndrome: current perspectives on diagnosis and management. Infection and Drug Resistance 2016;9:221-227
- Fehér. A Comparison of Current Guidelines of Five International Societies on Clostridium difficile Infection Management. J. Infect Dis Ther 2016;5(3):207-230
- Cózar-Llistó. Clostridium difficile Infection in Special High-Risk Populations. J. Infect Dis Ther 2016;5:253
- Van Oostendorp. Prehospital control of life-threatening truncal and junctional haemorrhage is the ultimate challenge in optimizing trauma care; a review of treatment options and their applicability in the civilian trauma setting. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2016;24:110
Supplement from the Indian Journal of Anaesthesia
- Kapoor. Types of studies and research design. Indian J Anaesth 2016;60:626-30
- Sudheesh. How to write a research proposal?. Indian J Anaesth 2016;60:631-4
- Grewal. Literature search for research planning and identification of research problem. Indian J Anaesth 2016;60:635-9
- Garg. Methodology for research I. Indian J Anaesth 2016;60:640-5
- Bhaskar. Methodology for research II. Indian J Anaesth 2016;60:646-51
- Das. Sample size calculation: Basic principles. Indian J Anaesth 2016;60:652-6
- Kulkarni. Interpretation and display of research results. Indian J Anaesth 2016;60:657-61
- Ali. Basic statistical tools in research and data analysis. Indian J Anaesth 2016;60:662-9
- Umesh. Critical appraisal of published literature. Indian J Anaesth 2016;60:670-3
- Bajwa. Preparing manuscript: Scientific writing for publication. Indian J Anaesth 2016;60:674-8
- Harsoor. Art and science of authorship for biomedical research publication. Indian J Anaesth 2016;60:679-83
- Yip. Legal and ethical issues in research. Indian J Anaesth 2016;60:684-8
- Sriganesh. A brief overview of systematic reviews and meta-analyses. Indian J Anaesth 2016;60:689-94
- Gurudatt. Case reports: Brief overview of reporting and submission to biomedical journal. Indian J Anaesth 2016;60:695-9
- Cesana. Basics to perform and present statistical analyses in scientific biomedical reports. Part 2. Minerva Anestesiologica 2016;82(9):935-9
- Horton. Data sharing—why editors may have got it wrong. Lancet 2016;388(10050):1143
- Harsoor. Learning research methodology: Revisiting the evidence. Indian J Anaesth 2016;60:619-21
- Kamath. Importance of evidence-based medicine on research and practice. Indian J Anaesth 2016;60:622-5
- Kulkarni. Role of transcranial doppler in cerebrovascular disease. Neurol India 2016;64:995
- Takaschimaa. Ethical and legal duty of anesthesiologists regarding Jehovah's Witness patient: care protocol. Brazilian Journal of Anesthesiology 2016;epublished September 12th
- Wachter. Zero to 50,000 — The 20th Anniversary of the Hospitalist. N Engl J Med 2016;375:1009-1011
- Gunderman. Hospitalists and the Decline of Comprehensive Care. N Engl J Med 2016; 375:1011-1013
- Chung-esaki. A 50-Year-Old Woman With a History of Hypertension and Tobacco Use Presenting With Hypoxia. Chest 2016;150(3):e73-e76
- Elbadawi. Fever in a Young Female: Unmasking a Rare Disaster. Chest 2016;150(3):e77-e79
- Mishra. Fatal Cerebral Air Embolism: A Case Series and Literature Review. Case Rep Crit Care 2016;2016:3425321
Once again the Critical Care Reviews Meeting will be discussing the biggest studies of the previous year with their chief investigators, asking the question "should we implement the results of this trial into our dialy practice?". We also have the John Hinds Trauma Lecture, delivered this year by Prof Donat Spahn (Zurich), lead for the new European Trauma Guideline, published a few months ago. Paul Marik thinks he has discovered "The Cure for Sepsis", while John Myburgh will explain the ins and outs of research methodology in the "Path to Truth". In addition, there is the very popular "How I Manage....." series of short talks from our speakers on conditions they are experts in, the "Year in Review" and the now famous "Informal Chat" in the bar after the main event.
Don't forget to register for dinner also, where the menu is based on an original menu from the only sailing the Titanic made. Registration for both the meeting and meal is available on the meeting webpage. The Critical Care Reviews Meeting is a not-for-profit event.
Following last year's massively successful event, the UK Intensive Care Society's State-of-the-Art Meeting is starting its build-up to 2016. The ICS completely changed its game in 2015, and relaunched SOA as a new beacon for forward-looking clinical content, open-access education, and medical social media. In keeping with the times, the podcasts and other materials from last year's meeting have been made open access.
This year the programme is looking even better, with topics ranging from the futuristic (space medicine, Formula 1 applied technology, Google Deepmind, and AI) through to the human, practical, and controversial (look out for the clinical scenarios, controversies, and the "From Ivory Tower to Desert Island" session). Speakers include Peter Brindley, Kevin Fong, Jack Iwashyna, Kath Maitland, Louise Rose, Mervyn Singer, and Jean-Louis Vincent among many others. It runs from Mon 5th - Wed 7th Dec, and I hope I'll see you there. Keep an eye on http://soa.ics.ac.uk for programme and registration, and meanwhile enjoy the comprehensive FOAM from last year.
(Image from Chensiyuan via Wikipedia)
This adult and paediatric ICM meeting is jointly organized by the Society of Intensive Care Medicine (SICM), Singapore and the Australia-New Zealand Intensive Care Society (ANZICS) and is scheduled for 20-24 April 2017 in Suntec Convention Centre, Singapore. It has grown from its humble beginnings in a small hospital venue to become one of the best ICM conference in the Asia-Pacific region. Past editions featured prominent speakers such as Jean Louis Vincent, Daniel De Backer, John J Marini, Rinaldo Bellomo amongst many others, and in this edition the list of distinguished international panel of speakers, program schedule and planned workshops look more impressive than ever. Beside the obvious educational benefits, this conference is also a great opportunity to experience the unique Singaporean culture, enjoy its famed gastronomy and visit its attractions.
Registration is yet to open so do subscribe to its newsletter at www.sg-anzics.com for updates.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week