Welcome to the 214th Critical Care Reviews Newsletter, bringing you the best research and open access articles from the critical care literature in the past week. Due to the build up to the Critical Care Reviews Meeting 2016, in just 12 days, there has been less time to prepare this week's edition. Having said that, there are still some fantastic pieces to read. The highlight of this newsletter is the updated Nutrition Guideline for Critically Ill Adults, a joint SCCM / ASPEN document. If you only have time for one paper this week, try this horizon scanning paper on alternatives to antibiotics.
The emphasis is now very much on the Critical Care Reviews Meeting 2016, being held at the Titanic Centre on Friday January 29th. With an international world class faculty discussing the biggest studies of 2015, this is the most contemporary critical care meeting available to attend. We are in the process of completing the booklet for the event, including detailed critiques of 30 of the most important studies from last year. Registration is still available on the meeting webpage.
- Abstract: Petros. Hypocaloric vs Normocaloric Nutrition in Critically Ill Patients. A Prospective Randomized Pilot Trial. JPEN J Parenter Enteral Nutr February 2016;40(2):242-249
- Abstract: Abdul-Aziz. Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Med 2016;epublished January 11th
- Abstract: Srivastava. Randomized Controlled Trial Comparing the Efficacy of Terlipressin and Albumin with a Combination of Concurrent Dopamine, Furosemide, and Albumin in Hepatorenal Syndrome. J Clin Exp Hepat 2015;5(4):276-285
- Full Text: Choudry. A randomized double-blind control study of early intra-coronary autologous bone marrow cell infusion in acute myocardial infarction: the REGENERATE-AMI clinical trial. Eur Heart J 2016;37:256-263
- Full Text: Davidson. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet 2015;387(10015):239-250
- Abstract: Tatucu-Babet. Prevalence of Underprescription or Overprescription of Energy Needs in Critically Ill Mechanically Ventilated Adults as Determined by Indirect Calorimetry. A Systematic Literature Review. JPEN J Parenter Enteral Nutr February 2016;40(2):212-225
- Abstract: Chughlay. N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review. Br J Clin Pharmacol 2016;epublished January 12th
- Full Text: Böttiger. Influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation: systematic review and meta-analysis. Critical Care 2016;20:4
- Full Text: Deye. Changes in cardiac arrest patients’ temperature management after the 2013 “TTM” trial: results from an international survey. Annals of Intensive Care 2016;6:4
- Full Text: Wiewel. Chronic antiplatelet therapy is not associated with alterations in the presentation, outcome, or host response biomarkers during sepsis: a propensity-matched analysis. Intensive Care Medicine 2016;epublished January 14th
- Abstract: Quraishi. Plasma 25-Hydroxyvitamin D Levels at Initiation of Care and Duration of Mechanical Ventilation in Critically Ill Surgical Patients. JPEN J Parenter Enteral Nutr February 2016;40(2):273-278JPEN J Parenter Enteral Nutr February 2016;40(2):273-278
- Abstract: Vermeulen. Taurine Concentrations Decrease in Critically Ill Patients With Shock Given Enteral Nutrition. JPEN J Parenter Enteral Nutr February 2016;40(2):264-272
- Abstract: de la Fuente. Enteral Nutrition in Patients Receiving Mechanical Ventilation in a Prone Position. JPEN J Parenter Enteral Nutr February 2016;40(2):250-255 JPEN J Parenter Enteral Nutr February 2016;40(2):250-255
- Abstract: Panchal. Safety of Enteral Feedings in Critically Ill Children Receiving Vasoactive Agents Graphic. JPEN J Parenter Enteral Nutr February 2016;40(2):236-241 JPEN J Parenter Enteral Nutr February 2016;40(2):236-241
- Full Text: Wong. Cardiovascular outcomes associated with use of clarithromycin: population based study. BMJ 2016;352:h6926
- Abstract: Lasa. Extracorporeal Cardiopulmonary Resuscitation (E-CPR) During Pediatric In-Hospital Cardiopulmonary Arrest Is Associated With Improved Survival to Discharge. A Report from the American Heart Association’s Get With The Guidelines–Resuscitation (GWTG-R) Registry. Circulation 2016;133:165-176
- Cortegiani. Antifungal agents for preventing fungal infections in non-neutropenic critically ill patients. Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD004920
- Wang. Semi-recumbent position versus supine position for the prevention of ventilator-associated pneumonia in adults requiring mechanical ventilation. Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD009946
- Guay. Epidural pain relief versus systemic opioid-based pain relief for abdominal aortic surgery. Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD005059
- Yoo. Anticoagulant treatment for subsegmental pulmonary embolism. Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD010222
- Lahousse. Cardiac effects of current treatments of chronic obstructive pulmonary disease. Lancet Respir Med 2016;epublished January 11th
- Güvença. Clinical presentation, diagnosis and management of acute mitral regurgitation following acute myocardial infarction. Journal of Acute Disease 2016;epublisjhed January 8th
- Gupta. Role of oral care to prevent VAP in mechanically ventilated Intensive Care Unit patients. Saudi J Anaesth 2016;10:95-7
- Chaudhry. Pathogenesis of Mycoplasma pneumoniae: An update. Indian J Med Microbiol 2016;34:7-16
- Czaplewski. Alternatives to antibiotics—a pipeline portfolio review. Lancet Infect Dis 2016;epublished January 12th
- Desserud. Emergency general surgery in the geriatric patient. Br J Surg 2016;103:e52–e61
- Ghaferi. Importance of teamwork, communication and culture on failure-to-rescue in the elderly. Br J Surg 2016;103:e47–e51
- Sutherland. Kidney and liver transplantation in the elderly. Br J Surg 2016;103:e62–e72
- DeFronzo. Metformin-associated lactic acidosis: Current perspectives on causes and risk. Metabolism Clinical & Experimental 2016;65(2):20-29
- Gulla. Illness severity and organ dysfunction scoring in Pediatric Intensive Care Unit. Indian J Crit Care Med 2016;20:27-35
- Modaresi. Irreversible pulpitis and achieving profound anesthesia: Complexities and managements. Anesth Essays Res 2016;10:3-6
- Khetarpal. Anesthetic considerations in the patients of chronic obstructive pulmonary disease undergoing laparoscopic surgeries. Anesth Essays Res 2016;10:7-12
- Dupont. Prone position acute respiratory distress syndrome patients: less prone to ventilator associated pneumonia? Intensive Care Medicine 2016;epublished January 14th
- Shime. Clinical and investigative critical care medicine in Japan. Intensive Care Medicine 2016;epublished January 13th
- Guérin. Acute cor pulmonale and the acute respiratory distress syndrome. Intensive Care Medicine 2016;epublished January 13th
- Aggarwal. Assessing the age of deep vein thrombus: A need for future perioperative medicine and anesthesia. Anesth Essays Res 2016;10:1-2
- Tsaousi. Is dexmedetomidine a favorable agent for cerebral hemodynamics?. Indian J Crit Care Med 2016;20:1-2
- Hall. Operating room conflict resolution: Time to figure it out. Saudi J Anaesth 2016;10:4-5
- Heffner. Tenth Edition of Antithrombotic Guidelines: Medical Professionalism and the Funnel of Knowledge. Chest 2016
- Sever. Acute kidney injury: highlights from the ERA-EDTA Congress in London. Nephrol Dial Transplant 2016;epublished January 13th
- Fuster. Stethoscope’s Prognosis: Very Much Alive and Very Necessary. J Am Coll Cardiol 2016;epublished January 15th
- Fauci. Zika Virus in the Americas — Yet Another Arbovirus Threat. N Engl J Med 2016;epublished January 13th
- Hulzebos. Making the elderly fit for surgery. Br J Surg 2016;103:e12–e15
- Bogoch. Anticipating the international spread of Zika virus from Brazil. Lancet 2016;epublished January 14th
- Pantazopoulos. Corticosteroids and inflammation after cardiac arrest. Resuscitation 2016;99:e7-e8
- Savitha. A modified submental orotracheal intubation. Anesth Essays Res 2016;10:132-5
- Parasa. Acute normovolemic hemodilution to avoid blood transfusion during intracranial aneurysm surgery in a patient with atypical antibodies. Anesth Essays Res 2016;10:136-8
- Saluja. Transesophageal echocardiography probe shutdown in a patient with hyperthermia. Indian J Crit Care Med 2016;20:50-1
- Fama. A fatal anal impalement. J Emerg Trauma Shock 2016;9:45
- Hateley. Pneumoperitoneum, a urological source. Lancet 2016;387(10015):284
Due to hugely successful previous events, the Critical Care Reviews Meeting 2016 has been moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic, As before, the meeting theme is to review the biggest studies of the previous year, with chief investigators present where possible to discuss their work in person. From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Dr Anthony Gordon (London, England), will review his VANISH study, a multi-centre randomized controlled trial comparing vasopressin with noradrenaline, with or without hydrocortisone, for first-line vasopressor support in septic shock. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. A new feature for the meeting is the John Hinds' Trauma Lecture, with Dr Brian Burns (Sydney HEMS, Australia) travelling across the world to deliver the inaugural presentation. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. Ton finish a fantastic day, we have a pre-dinner talk from a colleague of mine, Mr Chris Andrews, on "My Great Great Uncle Thomas Andrews - The Man Who Built Titanic".
With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. Don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.
The next SMACC Conference is on June 13th to 16th, in Dublin, Ireland. Registration opened on October 28th, sold out in a few hours, and closed again. Luckily, there are two further smaller batches of tickets available on Wednesday December 2nd and Wednesday February 3rd. With world leading academics and high profile clincians from the FOAMed critical care world, this conference fuses knowledge, dynamism and enthusiasm with an altruisitic desire to be the best we can be for the benefit of our patients. It's the most fun, modern critical care conference in the world. If you've been lucky enough to register for #smaccDUB, the presentations from SMACC Chicago, which are now online at Intensive Care Network, will give you an idea as to what to expect.
(Image from Wikimedia)
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week