Welcome to the 211th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals. It's a short issue, for obvious reasons, with its highlights being review articles on ICP monitoring, post cardiac arrest management, sepsis-induced acute kidney injury and antimicrobial stewardship, as well as a new ILCOR guideline on temperature management post cardiac arrest.
- Full Text: Fransen. Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke. JAMA Neurol 2015;epublished December 21st
- Abstract: Olivieri. New versus Conventional Helmet for Delivering Noninvasive Ventilation: A Physiologic, Crossover Randomized Study in Critically Ill Patients. Anesthesiology 2016;124:101-108
- Full Text: Azzopardi. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Lancet Neurology 2015;epublished December 18th
- Abstract: Malik. Microbial Cell Preparation (MCP) in Enteral Feeding in Critically Ill Patients: A Randomized, Double-blind, Placebo-controlled Clinical Trial. J Crit Care 2015;epublished December 14th
- Abstract: Egal. Targeting Oliguria Reversal in Goal-Directed Hemodynamic Management Does Not Reduce Renal Dysfunction in Perioperative and Critically Ill Patients: A Systematic Review and Meta Analysis. Anesth Analg 2016;122(1):173-185
- Abstract: Nagendran. Comparative safety and efficacy of vasopressors for mortality in septic shock: A network meta-analysis. JICS 2015;epublished December 17th
- Abstract: Tabah. A systematic review of the definitions, determinants and clinical outcomes of antimicrobial de-escalation in the intensive care unit. Clin Infect Dis 2015;epublished December 23rd
- Abstract: Umemura. Efficacy and safety of anticoagulant therapy in three specific populations with sepsis: a meta-analysis of randomized controlled trials. Journal of Thrombosis and Haemostasis 2015;epublished December 16th
- Full Text: Gillies. Fenoldopam to prevent acute kidney injury after major surgery—a systematic review and meta-analysis. Critical Care 2015;19:449
- Full Text: Sowers. Impact of the age of stored blood on trauma patient mortality: a systematic review. Can J Surg 2015;58(5):335-42
- Full Text: Ferrer. Polymicrobial intensive care unit-acquired pneumonia: prevalence, microbiology and outcome. Critical Care 2015;19:450
- Full Text: Jiroutková. Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness. Critical Care 2015;19:448
- Full Text: van Waes. Association between Intraoperative Hypotension and Myocardial Injury after Vascular Surgery. Anesthesiology 2016;124:35-44
- Full Text: Kang. Predictive value of EEG-awakening for behavioral awakening from coma. Annals of Intensive Care 2015;5:52
- Full Text: Becker. Clinical characteristics and outcome of very elderly patients ≥90 years in intensive care: a retrospective observational study. Annals of Intensive Care 2015;5:53
- Full Text: Chou. The role of brain natriuretic peptide in predicting renal outcome and fluid management in critically ill patients. J Formos Med Assoc 2015;epublished December 12th
- Abstract: Shrime. Time-Limited Trials of Intensive Care for Critically Ill Patients With Cancer: How Long Is Long Enough? JAMA Oncol 2015;15:1-8
- Abstract: Ayzac. Ventilator-associated pneumonia in ARDS patients: the impact of prone positioning. A secondary analysis of the PROSEVA trial. Intensive Care Med 2015;epublished December 23rd
- Abstract: Abdulaziz. What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients? J Antimicrob Chemother 2015;epublished December 24th
- Abstract: Constantin. Efficacy and safety of sedation with dexmedetomidine in critical care patients: A meta-analysis of randomized controlled trials. Anaesth Crit Care Pain Med 2015;epublished December 11th
- Futier. Fluid loading in abdominal surgery - saline versus hydroxyethyl starch (FLASH Trial): study protocol for a randomized controlled trial (FLASH Trial). Trials 2015;16:582
- Bailly. McGRATH MAC videolaryngoscope versus Macintosh laryngoscope for orotracheal intubation in intensive care patients: the randomised multicentre MACMAN trial study protocol. BMJ Open 2015;5(12):e009855
- Kawoos. Advances in Intracranial Pressure Monitoring and Its Significance in Managing Traumatic Brain Injury. Int J Mol Sci 2015;16(12):28979-97
- Roberts. Ventricular assist devices and non-cardiac surgery. BMC Anesthesiology 2015;15:185
- Tariq. Use of Inotropic Agents in Treatment of Systolic Heart Failure. Int J Mol Sci 2015;16(12):29060-8
- Topjian. Haemodynamic and ventilator management in patients following cardiac arrest. Curr Opin Crit Care 2015;21(3):195-201
- Saad. Ranolazine in Cardiac Arrhythmia. Clin Cardiol 2015;epublished October 13th
- Poletti. Invasive diagnostic techniques in idiopathic interstitial pneumonias. Respirology 2016;21:44–50
- Nguyen. Intra-abdominal Hypertension: An Important Consideration for Diuretic Resistance in Acute Decompensated Heart Failure. Clin Cardiol 2015;epublished December 20th
- Lewis. Control of bleeding in surgical procedures: critical appraisal of HEMOPATCH (Sealing Hemostat). Medical Devices: Evidence and Research 2016;9:1-10
- Honore. Prevention and treatment of sepsis-induced acute kidney injury: an update. Annals of Intensive Care 2015;5:51
- Brooks. Antimicrobial stewardship in the intensive care setting – a review and critical appraisal of the literature. Swiss Med Wkly. 2015;145:w14220
- Vincent. A Review of Management of Clostridium difficile Infection: Primary and Recurrence. Antibiotics 2015;4(4):411-423
- Mathias. A Review of GM-CSF Therapy in Sepsis. Medicine 2015;94(50):e2044
- Yahavab. Bloodstream infections in older patients – a review. Virulence 2015;epublished December 10th
- Dryden. Target-Controlled Infusions: Paths to Approval. Anesthesia & Analgesia 2015;122(1):86-89
- Nanji. Evaluation of Perioperative Medication Errors and Adverse Drug Events. Anesthesiology 2016;124:25-34
- Donnino. Temperature Management After Cardiac Arrest: An Advisory Statement by the Advanced Life Support Task Force of the International Liaison Committee on Resuscitation and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. Circulation 2015;132:2448-2456
- Demaerschalk. Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2015;epublished December 22nd
Due to hugely successful previous events, the Critical Care Reviews Meeting 2016 has been moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic, As before, the meeting theme is to review the biggest studies of the previous year, with chief investigators present where possible to discuss their work in person. From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Dr Anthony Gordon (London, England), will review his VANISH study, a multi-centre randomized controlled trial comparing vasopressin with noradrenaline, with or without hydrocortisone, for first-line vasopressor support in septic shock. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. A new feature for the meeting is the John Hinds' Trauma Lecture, with Dr Brian Burns (Sydney HEMS, Australia) travelling across the world to deliver the inaugural presentation. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. Ton finish a fantastic day, we have a pre-dinner talk from a colleague of mine, Mr Chris Andrews, on "My Great Great Uncle Thomas Andrews - The Man Who Built Titanic".
With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. Don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.
The next SMACC Conference is on June 13th to 16th, in Dublin, Ireland. Registration opened on October 28th, sold out in a few hours, and closed again. It opened again on December 2nd and sold out in just 15 minutes. Luckily, there is a further batch of tickets available on Wednesday February 3rd. With world leading academics and high profile clincians from the FOAMed critical care world, this conference fuses knowledge, dynamism and enthusiasm with an altruisitic desire to be the best we can be for the benefit of our patients. It's the most fun, modern critical care conference in the world. If you've been lucky enough to register for #smaccDUB, the presentations from SMACC Chicago, which are now online at Intensive Care Network, will give you an idea as to what to expect.
(Image from Wikimedia)
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
Best wishes for 2016.
Until next week.