A beautiful tribute from my hometown newspaper, the Irish Examiner, to the late New Zealand All Black Jonah Lomu, who died this week aged just 40. His name belongs alongside sporting greats Pele, Muhammad Ali, Nadia Comăneci, Michael Jordan and Usain Bolt, as one of few sportsmen and women who changed their sport forever. I was lucky enough to see him play in Dublin in 2001.
Welcome to the 206th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.
It's been a quiet week for research publications, but this has been balanced by a number fantastic review articles, including papers on the haemodynamic management of septic shock, fluid responsiveness in acute circulatory failure, hyperoxia, and critical care ultrasound in cardiac arrest. If you only have time to read one paper, try this one on personalizing blood pressure management in septic shock.
On the meeting front, time is running out to register for the Intensive Care Society's annual State-of-the-Art meeting in London in a fortnight. This weekend, the International Fluid Academy meeting is on in Antwerp, starting on Friday. It's just 8 days until the second release of registrations for the SMACC conference in Dublin in June. As a special feature for the Critical Care Reviews Meeting 2016, I'm delighted to announce a pre-dinner talk from Mr Chris Andrews, an orthopaedic consultant and colleague of mine in Belfast, on "My Great Great Uncle Thomas Andrews - The Man Who Built Titanic". For those of you familiar with the 1997 movie from James Cameron, Thomas Andrews, the designer of Titanic, had a central role in this film. With insights on his life, the building of the great ship and tales from its only voyage, this will be a fantastic prelude to the meeting dinner, overlooking the slipway where Titanic was built.
This week's Topic of the Week is a series of papers based on the International Fluid Academy Meeting, starting with a paper entitled "Fluid therapy in critically ill patients: perspectives from the right heart" in tomorrow's Paper of the Day.
- Full Text: Belletti. Non-Adrenergic Vasopressors in Patients with or at Risk for Vasodilatory Shock. A Systematic Review and Meta-Analysis of Randomized Trials. PLoS ONE 2015;10(11):e0142605
- Full Text: Liu. Risks and benefits of stress ulcer prophylaxis in adult neurocritical care patients: a systematic review and meta-analysis of randomized controlled trials. Critical Care 2015;19:409
- Abstract: Reith. The reliability of the Glasgow Coma Scale: a systematic review. Intensive Care Med 2015;epublished November 12th
- Abstract: Zhou. Preoperative Acute Normovolemic Hemodilution for Minimizing Allogeneic Blood Transfusion: A Meta-Analysis. Anesthesia & Analgesia 2015;12(6):1443-1455
- Full Text: Ospina-Tascón. Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock? Intensive Care Med 2015;epublished November 17th
- Abstract: Jung. Diaphragmatic dysfunction in patients with ICU-acquired weakness and its impact on extubation failure. Intensive Care Med 2015;epublished November 16th
- Full Text Thomas. A Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States. Critical Care Med 2015;43(12):2527-2534
- Abstract: Shokoohi. Bedside Ultrasound Reduces Diagnostic Uncertainty and Guides Resuscitation in Patients With Undifferentiated Hypotension. Critical Care Med 2015;43(12):2562–2569
- Abstract: Sakr. Being Overweight Is Associated With Greater Survival in ICU Patients: Results From the Intensive Care Over Nations Audit. Critical Care Med 2015;43(12):2623–2632
- Abstract: Lansink-Hartgring. Hospital Costs Of Extracorporeal Life Support Therapy. Critical Care Med 2015;epublished November 13th
- Abstract: Helmerhorst. Effectiveness and Clinical Outcomes of a Two-Step Implementation of Conservative Oxygenation Targets in Critically Ill Patients: A Before and After Trial. Critical Care Med 2015;epublished November 13th
- Abstract: Halmin. Epidemiology of Massive Transfusion: A Binational Study From Sweden and Denmark. Critical Care Med 2015;epublished November 6th
- Full Text: Goto. Neurological outcomes in children dead on hospital arrival. Critical Care 2015;19:410
- Algie. Effectiveness and risks of cricoid pressure during rapid sequence induction for endotracheal intubation. Cochrane Database of Systematic Reviews 2015, Issue 11. Art. No.: CD011656
- Ogunlesi. Adjuvant corticosteroids for reducing death in neonatal bacterial meningitis. Cochrane Database of Systematic Reviews 2015, Issue 11. Art. No.: CD010435
- Viswanath. Emergence delirium: a narrative review. Journal of Anesthesiology & Clinical Science 2015;4:2
- Flynn. Advances in the understanding of delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage. F1000Research 2015;4:1200
- Hasanin. Fluid responsiveness in acute circulatory failure. Journal of Intensive Care 2015;3:50
- Schwartz. Cardiac Arrhythmias in a Septic ICU Population: A Review. The Journal of Critical Care Medicine 2015;1(4):140-146
- Novak. Ventricular Septal Rupture – A Critical Condition as a Complication of Acute Myocardial Infarction. The Journal of Critical Care Medicine 2015;1(4):162–166
- Peeters. An overview on fluid resuscitation and resuscitation endpoints in burns: Past, present and future. Part 2 — avoiding complications by using the right endpoints with a new personalized protocolized approach. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Poelaert. Assessment of loading conditions with cardiac ultrasound. A comprehensive review. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Elbers. Fluid therapy in critically ill patients: perspectives from the right heart. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Joosten. Perioperative goal directed therapy using automated closed-loop fluid management: the future? Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Lichtenstein. Critical care ultrasound in cardiac arrest. Technological requirements for performing the SESAME-protocol — a holistic approach. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Peeters. Hemodynamic monitoring: To calibrate or not to calibrate? Part 1 – Calibrated techniques. Anaesthesiology Intensive Therapy. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXXAnaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Bernards. Hemodynamic monitoring: To calibrate or not to calibrate? Part 2 — Non-calibrated techniques. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Pollesello. Calcium sensitizers: What have we learned over the last 25years? Int J Cardiol 2015;203:543-548
- Zima. Sudden Cardiac Death and Post Cardiac Arrest Syndrome. An Overview. The Journal of Critical Care Medicine 2015;1(4):167–170
- Vohra. Update on the Diagnosis and Management of Brugada Syndrome. Heart, Lung and Circulation 2015;24:1141–1148
- Ferreira. Atrial Fibrillation and Non-cardiovascular Diseases: A Systematic Review. Arq Bras Cardiol 2015;105(5):519–526
- Benedek. Current Concepts and New Trends in the Treatment of Cardiogenic Shock Complicating Acute Myocardial Infarction. The Journal of Critical Care Medicine 2015;1(1):5–10
- Mietto. Transpulmonary pressure monitoring during mechanical ventilation: a bench-to-bedside review. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Hafner. Hyperoxia in intensive care, emergency, and peri-operative medicine: Dr. Jekyll or Mr. Hyde? A 2015 update. Annals of Intensive Care 2015;5:42
- Kamaly. Beyond the fire: smoke inhalational injury as a respiratory concern. Ain-Shams J Anaesthesiol 2015;8:283-6
- Al Jaaly. Pulmonary Protection Strategies in Cardiac Surgery: Are We Making Any Progress? Oxid Med Cell Longev 2015;2015:416235
- Soluri-Martins. How to minimise ventilator-induced lung injury in transplanted lungs: The role of protective ventilation and other strategies. Eur J Anaesthesiol 2015; 32:828–836
- Soleimanpour. Hepatic Shock Differential Diagnosis and Risk Factors: A Review Article. Hepat Mon 2015;15(10):e27063
- Bihorac. Acute Kidney Injury in the Surgical Patient: Recognition and Attribution. Nephron 2015;131:118-122
- Lipcsey. Hemodynamic management of septic shock. Minerva Anestesiologica 2015;81(11):1262-72
- Kato. Personalizing blood pressure management in septic shock. Annals of Intensive Care 2015;5:41
- Vandervelden. Initial resuscitation from severe sepsis: one size does not fit all. Anaesthesiology Intensive Therapy 2015;47(5):XXX–XXX
- Daniela. Invasive Candida Infections in the ICU: Diagnosis and Therapy. The Journal of Critical Care Medicine 2015;1(4):129–139
- Pati. Cellular Therapies in Trauma and Critical Care Medicine: Forging New Frontiers. Shock 2015;44(6):505–523
- Luca. Oxidative Stress and Antioxidant Therapy in Critically Ill Polytrauma Patients with Severe Head Injury. The Journal of Critical Care Medicine 2015;1(3):83–91
- Kalabalik. Use of Dexmedetomidine in the Management of Alcohol Withdrawal Syndrome in Critically Ill Patients. Int J Crit Care Emerg Med 2015;1:1
- Oliver. Risk assessment tools validated for patients undergoing emergency laparotomy: a systematic review. Br J Anaesth 2015;115:849-860
- Ural. Diagnosis and management of acute heart failure. Anatol J Cardiol 2015;15:860-889
- Deballon. Protocols for Uncontrolled Donation after Circulatory Death: International & Comprehensive Analysis. Int J Crit Care Emerg Med 2015;1:001e
- Barry. Guidelines for Classification of Acute Kidney Diseases and Disorders. Nephron 2015;epublished November 11th
- Flores-Franco. Acquired Tracheal Diverticulum as an Unexpected Cause of Endotracheal Tube Cuff Leak. The Journal of Critical Care Medicine 2015;1(4):171–173
- Naik. Delayed Recovery from General Anaesthesia: A Post-operative Diagnostic Dilemma and Implications of ICU Management of Serotonin Toxicity. Case report. The Journal of Critical Care Medicine 2015;1(4):174–178
- Haytham. Tension Pneumoperitoneum. N Engl J Med 2015;373:e24
Due to hugely successful previous events, the Critical Care Reviews Meeting 2016 has been moved to a brand new venue, the stunning, multi-million pound Titanic Centre, birthplace of RMS Titanic, As before, the meeting theme is to review the biggest studies of the previous year, with chief investigators present where possible to discuss their work in person. From Wellington, New Zealand, Dr Paul Young will talk on his studies SPLIT (saline versus plasmalyte) and HEAT (paracetamol for pyrexia control). Dr John Holcomb (Houston, USA) will review his mega trial PROPPR, evaluating blood product transfusion ratios in traumatic haemorrhage. Dr Anthony Gordon (London, England), will review his VANISH study, a multi-centre randomized controlled trial comparing vasopressin with noradrenaline, with or without hydrocortisone, for first-line vasopressor support in septic shock. Prof Tim Walsh (Edinburgh, Scotland) will review the ABLE study, including his ABLE UK component, evaluating age of transfused red cells, as well as RECOVER, a post-ICU rehab study. In addition, two of the most eminent intensivists in global critical care, Prof Jean-Louis Vincent (Brussels, Belgium) and Prof Luciano Gattinoni (Milan, Italy) will be on hand to discuss the significance of these findings. A new feature for the meeting is the John Hinds' Trauma Lecture, with Dr Brian Burns (Sydney HEMS, Australia) travelling across the world to deliver the inaugural presentation. It won't be all study discussion, with other elements to the meeting, including the spectacularly popular "Informal Chat", taking place that evening.
If you haven't yet attended this modern, niche meeting, then put the date Friday January 29th in your diary. Both delegate and speaker feedback from previous meetings has been incredibly positive, allowing the event to grow and attract some of the biggest names in critical care. The Titanic Centre is just minutes from Belfast City Airport, with a hotel within 3 minutes walking distance, and is a 20 minute walk from the city centre, including the Cathedral Quarter, Belfast's cultural centre full of great restaurants and pubs. Further details regarding delegate rate accommodation should be available in the next week or two. Talks are given in the setting of the rebuilt famous staircase from the great ship, while both the "Informal Chat" session and dinner overlook the floodlit slipways where Titanic and Olympic were launched. Ton finish a fantastic day, we have a pre-dinner talk from a colleague of mine, Mr Chris Andrews, on "My Great Great Uncle Thomas Andrews - The Man Who Built Titanic".
With some exciting new innovations planned, this new meeting promises to delivery on its burgeoning reputation. Don't wait too long before registering, as numbers are capped to keep this an intimate event. It is as strong a one day programme as you could possibly find. If you think your colleagues would find this event interesting, please circulate this information - this is a not-for-profit event, run in association with the Northern Ireland Intensive Care Society.
The next SMACC Conference is on June 13th to 16th, in Dublin, Ireland. Registration opened on October 28th, sold out in a few hours, and closed again. Luckily, there are two further smaller batches of tickets available on Wednesday December 2nd and Wednesday February 3rd. With world leading academics and high profile clincians from the FOAMed critical care world, this conference fuses knowledge, dynamism and enthusiasm with an altruisitic desire to be the best we can be for the benefit of our patients. It's the most fun, modern critical care conference in the world. If you've been lucky enough to register for #smaccDUB, the presentations from SMACC Chicago, which are now online at Intensive Care Network, will give you an idea as to what to expect.
(Image from Wikimedia)
This year's State-of-the-Art Meeting promises an exciting programme in a new dynamic format. It aims to be the first major national society to fully embrace social media and free open access medical education, with an opening plenary session and a workshop, as well full integration of Twitter questions into sessions, live blogging, and open-access AV materials.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week