Welcome to the 194th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.
It's a packed newsletter including RCTs on perioperative bridging anticoagulation and emergency SVT treatment, meta analyses on fluids, statins in sepsis and vasopressors in sepsis, plus observational studies on the prehospital use of plasma and red cells in trauma, from #CCR16 speaker Dr John Holcomb, and a registry study on adrenaline in paediatric cardiac arrest. There is also a British guideline on the ICU admission of patients with haematological malignancy, and numerous excellent review articles, including papers on early goal-directed therapy, post-operative fluid management, perioperative analphylaxis, HIT and haemodynamic monitoring. There's even a book on paediatric anaesthesia & critical care, from the Journal of the World Federation of Societies of Anaesthesiologists.
The big news this week is the late addition of Dr Anthony Gordon to the Critical Care Reviews Meeting programme. Dr Gordon is the chief investigator for the VANISH study, a multi-centre randomized controlled factorial trial comparing vasopressin with noradrenaline, with or without hydrocortisone, for first-line vasopressor support in septic shock. This study will also be presented at the prestigous ESICM Hot Topics Session in Berlin in October, where Dr Gordon will join another CCR16 speaker, Dr Paul Young, presenting his much anticipated HEAT and SPLIT trials.
The University of Cambridge are offering a Masters in Clinical Medicine (Intensive Care Medicine), aimed at peri/post CCT trainees from the UK and overseas who aspire to tertiary centre consultant positions. This two year course incorporates concepts within FOAMed and the wider distributed education networks, requiring students to interact with SoMe and FOAM as part of their assessments. The two year programme comprises:
- A one year part time PGCert, consisting of modules in clinical research, clinical leadership, and clinical education.
- A two year part time MSt, which typically runs concurrently with the PGCert and consists of a broad range of modules in sub-speciality intensive care medicine and a research dissertation.
- Full Text: Douketis. Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation (BRIDGE Trial). N Eng J Med 2015;epublished June 22nd
- Full Text: Appelboam. Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial (REVERT trial). Lancet. 2015;epublished online Aug 25th
- Abstract: Daley. Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial. Lancet Infect Dis 2015;15(5):528-534
- Abstract: Alam. Perioperative elafin for ischaemia-reperfusion injury during coronary artery bypass graft surgery: a randomised-controlled trial. Heart 2015;epublished August 26th
- Abstract: Lavi. One-year outcome of the sevoflurane in acute myocardial infarction randomized trial. Canadian Journal of Anesthesia 2015;epublished August 22nd
- Abstract: Piazza. A Prospective, Single-Arm, Multicenter Trial of Ultrasound-Facilitated, Catheter-Directed, Low-Dose Fibrinolysis for Acute Massive and Submassive Pulmonary Embolism: The SEATTLE II Study. J Am Coll Cardiol Intv 2015;8(10):1382
- Abstract: Motov. Intravenous Subdissociative-Dose Ketamine Versus Morphine for Analgesia in the Emergency Department: A Randomized Controlled Trial. Annals of Emergency Medicine 2015;66(3):222–229.e1
- Full Text: Ripollés. Colloids versus crystalloids in objective-guided fluid therapy, systematic review and meta-analysis. Too early or too late to draw conclusions. Rev Bras Anestesiol 2015;65(4)
- Abstract: Yang. Effects of statins on the mortality and mechanical ventilation duration of acute lung injury patients: a meta-analysis of five randomized controlled trials. Int J Clin Pharmacol Ther 2015;epublished August 26th
- Abstract: Avni. Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis. PLOS One 2015;epublished August 3rd
- Full Text: Ripollés. Analgesic efficacy of the ultrasound-guided blockade of the transversus abdominis plane---a systematic review. Rev Bras Anestesiol 2015;65(4):255-280
- Full Text: Holcomb. Prehospital Transfusion of Plasma and Red Blood Cells in Trauma Patients. Prehospital Emergency Care 2015;19(1):1-9
- Abstract: Andersen. Time to Epinephrine and Survival After Pediatric In-Hospital Cardiac Arrest. JAMA 2015;314(8):802
- Full Text: Ibrahim. Cerebral Oximetry as a Real‐Time Monitoring Tool to Assess Quality of In‐Hospital Cardiopulmonary Resuscitation and Post Cardiac Arrest Care. J Am Heart Assoc 2015;4:e001859
- Abstract: Guerra. Survival and Neurocognitive Outcomes in Pediatric Extracorporeal-Cardiopulmonary Resuscitation. Resuscitation 2015;epublished August 21st
- Abstract: Heyland. Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study. Intensive Care Med 2015;epublished August 26th
- Full Text: Zhao. Prognostic value of extravascular lung water assessed with lung ultrasound score by chest sonography in patients with acute respiratory distress syndrome. BMC Pulm Med 2015;15:98
- Abstract: Ewy. The time dependent association of adrenaline administration and survival from out-of-hospital cardiac arrest. Resuscitation 2015;epublished August 22nd
- Abstract: Huang. The Efficacy and Safety of Prehospital Therapeutic Hypothermia in Patients with Out-of-hospital cardiac arrest: A Systematic Review and Meta-Analysis. Resuscitation 2015;epublished August 20th
- Abstract: Zeiner. Mechanical Chest Compression Does Not Seem to Improve Outcome after Out-Of Hospital Cardiac Arrest. A single Center Observational Trial. Resuscitation 2015;epublished August 21st
- Full Text: Oh. Continuous Amplitude-Integrated Electroencephalographic Monitoring is a Useful Prognostic Tool for Hypothermia-Treated Cardiac Arrest Patients. Circulation 2015;epublished August 12th
- Abstract: Britt. Comparison of the Effectiveness and Safety of Linezolid and Daptomycin in Vancomycin-Resistant Enterococcal Bloodstream Infection: A National Cohort Study of Veterans Affairs Patients. Clin Infect Dis 2015;61(6):871-878
- Godoy. Steps to consider in the approach and management of critically ill patient with spontaneous intracerebral hemorrhage. World J Crit Care Med 2015;4(3):213–229
- Mrozek. Brain-lung crosstalk: Implications for neurocritical care patients. World J Crit Care Med 2015;4(3):163-178
- Veselis. Memory formation during anaesthesia: plausibility of a neurophysiological basis. Br J Anaesth 2015;115(suppl 1):i13-i19
- Mashour. Intraoperative awareness: controversies and non-controversies. Br J Anaesth 2015;115(suppl 1):i20-i26
- Hagihira. Changes in the electroencephalogram during anaesthesia and their physiological basis. Br J Anaesth 2015;115(suppl 1):i27-i31
- Pandit. Interpretations of responses using the isolated forearm technique in general anaesthesia: a debate. Br J Anaesth 2015;115(suppl 1):i32-i45
- Sakka. Hemodynamic monitoring in the critically ill patient – current status and perspective. Front Med 2015;epublished August 3rd
- Kayilioglu. Postoperative fluid management. World J Crit Care Med 2015;4(3):192–201
- Grimm. Late complications following continuous-flow left ventricular assist device implantation. Front Surg 2015;2:42
- Bonacchi. Mechanical ventricular assistance as destination therapy for end-stage heart failure: has it become a first line therapy? Front Surg 2015;2:35
- Peter. Severe scrub typhus infection: Clinical features, diagnostic challenges and management. World J Crit Care Med 2015;4(3):244–250
- Jensen. The use of transcatheter aortic valve replacement vs surgical aortic valve replacement for the treatment of aortic stenosis. Research Reports in Clinical Cardiology 2015;6:105-116
- Binoun-A-Egom. B-type natriuretic peptide and heart failure: what can we learn from clinical trials?. Clinical and Experimental Pharmacology and Physiology 2015;42:881–887
- Longworth. Pyogenic liver abscess. Clinical Liver Disease 2015;6:51–54
- Cornely. Hepatosplenic candidiasis. Clinical Liver Disease 2015;6:47–50
- Anesi. Amebic liver abscess. Clinical Liver Disease 2015;6:41–43
- Pai. Cardiorenal syndrome. Hong Kong Journal of Nephrology 2015;epublished August 18th
- Sobhonslidsuk. Current position of vasoconstrictor and albumin infusion for type 1 hepatorenal syndrome. World J Gastrointest Pharmacol Ther 2015;6(3):28-31
- Gupta. Heparin induced thrombocytopenia in critically ill: Diagnostic dilemmas and management conundrums. World J Crit Care Med 2015;4(3):202–212
- Lei. Perioperative Red Blood Cell Transfusion: What We Do Not Know. Chin Med J 2015;128:2383-6
- Monsef. Optimal management of perioperative anemia: current perspectives. International Journal of Clinical Transfusion Medicine 2015;3:65-73
- Nantsupawat. Rivaroxaban monograph. SWRCCC 2015;3(10):27-33
- Mandernach. Apixaban for the prophylaxis and treatment of deep vein thrombosis and pulmonary embolism: an evidence-based review. Therapeutics and Clinical Risk Management 2015;11:1273-1282
- Gupta. Early goal-directed resuscitation of patients with septic shock: current evidence and future directions. Critical Care 2015;19:286
- Hendaus. Virus-induced secondary bacterial infection: a concise review. Therapeutics and Clinical Risk Management 2015;11:1265—1271
- Donald. Para-aminosalicylic acid: the return of an old friend. Lancet Infectious Diseases 2015;15(9):1091–1099
- Wise. Guidelines on the management and admission to intensive care of critically ill adult patients with haematological malignancy in the UK. British Journal of Haematology 2015;epublished August 19th
- Coccolini. Liver trauma: WSES position paper. World J Emerg Surg 2015;10:39
- Berbari. 2015 Infectious Diseases Society of America (IDSA) Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults. Clin Infect Dis 2015 61: 859-863: Executive Summary | Full Guideline
- Ñamendys-Silva. Opening the doors of the intensive care unit to cancer patients: A current perspective. World J Crit Care Med 2015;4(3):159–162
- Kurata. Memory and awareness in anaesthesia. Br J Anaesth 2015;115(suppl 1):i1-i3
- Veselis. What about β? Relationship between pain and EEG spindles during anaesthesia. Br J Anaesth 2015;115(suppl 1):i3-i5
- Hudson. Some heightened sensitivity. Br J Anaesth 2015;115(suppl 1):i5-i8
- Avidan. The diving bell and the butterfly. Br J Anaesth 2015;115(suppl 1):i8-i10
- Schneider. Restrict relaxants, be aware, and know the limitations of your depth of anaesthesia monitor. Br J Anaesth 2015;115(suppl 1):i11-i12
- Gottlieb. What Is the Clinical Utility of Bedside Ultrasonography in the Diagnosis of Acute Cardiogenic Pulmonary Edema in the Undifferentiated Dyspneic Patient? Annals of Emergency Medicine 2015;66(3):283-284
- Barrett. Move Over Morphine: Is Ketamine an Effective and Safe Alternative for Treating Acute Pain? Annals of Emergency Medicine 2015;66(3):336–337
- Brown. Clinical Policy: Use of Intravenous Tissue Plasminogen Activator for the Management of Acute Ischemic Stroke in the Emergency Department. Annals of Emergency Medicine 2015;66(3):322–333.e31
- Kellermann. Bringing a Battlefield Lesson Home. Academic Emergency Medicine 2015;epublished August 20th
- Honeybul. Outcome Following Decompressive Hemicraniectomy for Malignant Cerebral Infarction: Ethical Considerations. Stroke 2015;46:2695-2698
- Lanspa. Clinical study replicability and the pursuit of excellence. Critical Care 2015;19:297
- Hargreaves. Five questions to consider before conducting a stepped wedge trial. Trials 2015;16:350
- Copas. Designing a stepped wedge trial: three main designs, carry-over effects and randomisation approaches. Trials 2015;16:352
The big news this week is the late addition of Dr Anthony Gordon to the Critical Care Reviews Meeting programme. Dr Gordon is the chief investigator for the VANISH study, a multi-centre randomized controlled trial comparing vasopressin with noradrenaline, with or without hydrocortisone, for first-line vasopressor support in septic shock. This study will also be presented at the prestigous ESICM Hot Topics Session in Berlin in October, where Dr Gordon will join another CCR16 speaker, Dr Paul Young, presenting his much anticipated HEAT and SPLIT trials. Registrations are flowing in, and numbers are limited, so don't leave it too late to join us at the stunning Titanic Centre in Belfast, on Friday January 29th, to discuss the biggest studies of the year. The programme and registrations are available on the meeting webpage. Hotel accommodation will be added to the website this week and includes 3*, 4* and 5* hotels with deals especially for the meeting. The Titanic Centre, birthplace of the RMS Titanic, is a two minute drive from Belfast City Airport and just 20 minutes from Belfast International Airport.
Under the inspired guidance of meeting organiser Ganesh Suntharalingam, this year's State-of-the-Art Meeting promises an exciting programme in a new dynamic format. It aims to be the first major national society to fully embrace social media and free open access medical education, with an opening plenary session and a workshop, as well full integration of Twitter questions into sessions, live blogging, and open-access AV materials.
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. If you have an idea for a paper, and can say it in an engaging manner, please get in touch. We also need peer reviewers.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week