Welcome to the 176th Critical Care Reviews Newsletter, bringing you the best critical care research published in the past week, plus a wide range of free full text review articles, guidelines, commentaries, editorials, study critiques, correspondence and case reports from hundreds of clinical and scientific journals.
The highlight of this week's newsletter is the publication of the RECOVER randomized controlled trial by Prof Tim Walsh (Edinburgh), one of the featured studies for in-depth discussion at the Critical Care Reviews Meeting 2016. In addition, there are several other interesting RCTs, including high flow nasal oxygen for rapid sequence intubation in hypoxaemic ICU patients, ex-vivo perfusion of donor hearts for heart transplantation, another trial on corticosteroids for community-acquired pneumonia, plus the latest in a series of studies on endovascular therapies for stroke. There is also a case series documenting heart transplantation after organ recovery from non-heart beating donors, as well as guidelines / position statements on perioperative fluids, hyperglycaemia and sedation. If you only have time for one paper this week, try this one on management of severe sepsis: advances, challenges, and current status.
If you haven't yet registered, now is the time to do so. SMACC is the most innovative, invigorating, inspiring and fun critical care conference available. In just 10 weeks, delegates from across the world will converge on Chicago for the third running of this incredible event. With an emphasis on TED style presentations, minimal slides and maximal social media involvement, this is the future of medical meetings. In addition to numerous world-leading academics, many active in the altruistic social media world of FOAM are there to contribute, including helping deliver a massive set of workshops the day before the main meeting begins. Just like the Critical Care Reviews Meeting, this is a not-for-profit event, run by a team interested in sharing knowledge in a fun, modern way. It's a conference like no other. I hope to see you there.
The 2015 State-of-the-Art Meeting promises to be a much changed event. With a strong input from social media, the meeting has embraced new and exciting ideas to be delivered by a fantastic faculty. Check out the new website, due to launch later this week. More details will be available in next week's newsletter when they are available.
The ICSI host a superb three day ESICM meeting at Dubin Castle on June 11th to 13th, focusing on every aspect of respiratory critical care. From mechanical ventilation to ARDS to heart-lung interactions, this event is ideal for anyone interested in updating their knowledge in this field, under the guidance of some of the leading names in the area.
It may be 9 months away, but already there have been delegates registering from across the UK and Ireland for the 2016 meeting, at the Titanic Centre, Belfast. Once again we aim to review the major studies of the previous year with chief investigators present to discuss their work. Located beside an airport, and within walking distance of the city centre, this meeting has been optimised for the travelling delegate. Numbers are capped so don't wait too long before securing your place. Join us on January 29th for a world class meeting in a world class venue.
- Abstract: Walsh. Increased Hospital-Based Physical Rehabilitation and Information Provision After Intensive Care Unit Discharge. The RECOVER Randomized Clinical Trial. JAMA Intern Med 2015;epublished April 13th
- Abstract: Vourc'h. High-flow nasal cannula oxygen during endotracheal intubation in hypoxemic patients: a randomized controlled clinical trial. Intensive Care Med 2015;epublished April 14th
- Abstract: Ardehali. Ex-vivo perfusion of donor hearts for human heart transplantation (PROCEED II): a prospective, open-label, multicentre, randomised non-inferiority trial. Lancet 2015;epublished April 14th
- Full Text: Payen. Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial (ABDOMIX study). Intensive Care Med 2015;epublished April 11th
- Full Text: Mendelow. Early surgery versus initial conservative treatment in patients with traumatic intracerebral haemorrhage [STITCH(Trauma)]: the first randomised trial. J Neurotrauma 2015;epublished April 13th
- Full Text: Saver. Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke (SWIFT PRIME Trial). N Engl J Med 2015;epublished April 17th
- Abstract: Alvis. Randomized controlled trial comparing the McGrath MAC video laryngoscope with the King Vision video laryngoscope in adult patients. Minerva Anestesiol 2015;epublished April 17th
- Abstract: Semler. An Electronic Tool for the Evaluation and Treatment of Sepsis in the ICU: A Randomized Controlled Trial. Crit Care Med 2015;epublished April 10th
- Abstract: Blum. Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet 2015;385(9977):1511–1518
- Full Text: Grieve. Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: one-year outcomes from the IMPROVE randomized trial. European Heart Journal 2015;epublished April 8th
- Abstract: Manzanares. Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis. Critical Care 2015;19:167
- Abstract: van Sluisveld. Improving clinical handover between intensive care unit and general ward professionals at intensive care unit discharge. Intensive Care Med 2015;41(4):589-604
- Full Text: Reichlin. Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay. CMAJ 2015;epublished April 13th
- Full Text: Li. Neurocognitive Dysfunction Risk Alleviation With the Use of Dexmedetomidine in Perioperative Conditions or as ICU Sedation: A Meta-Analysis. Medicine 2015;94(14):e597
- Abstract: Holcomb. Comprehensive Injury Research. JAMA 2015;313(14):1463-1464
- Abstract: Kang. Failure of high-flow nasal cannula therapy may delay intubation and increase mortality. Intensive Care Med 2015;41(4):623-632
- Abstract: Suzuki. Paracetamol therapy and outcome of critically ill patients: a multicenter retrospective observational study. Critical Care 2015;19:162
- Abstract: Meltzer. Estimates of the Demand for Mechanical Ventilation in the United States During an Influenza Pandemic. Clin Infect Dis 2015;60:S52-S57
- Abstract: Dhital. Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series. Lancet 2015;epublished April 14th
- Full Text: Herrero-Puente. Influence of Intravenous Nitrate Treatment on Early Mortality Among Patients With Acute Heart Failure. NITRO-EAHFE Study. Rev Esp Cardiol (Engl Ed) 2015;April 8th
- Abstract: Tagami. Intravenous Immunoglobulin and Mortality in Pneumonia Patients with Septic Shock: An Observational Nationwide Study. Clin Infect Dis 2015;epublished April 16th
- Abstract: Krag. SUP-ICU Collaborators (2015), Stress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries. Acta Anaesthesiologica Scandinavica 2015;59:576–585
- Abstract: Barbaro. Association of Hospital-Level Volume of Extracorporeal Membrane Oxygenation Cases and Mortality. Analysis of the Extracorporeal Life Support Organization Registry. Am J Respir Crit Care Med 2015;191(8):894-901
- Abstract: Kibuuka. Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial. Lancet 2015;385(9977):1545–1554
- Abstract: Gustot. Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis. Hepatology 2015;epublished April 15th
- Abstract: Parry-Jones. Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage. Annals of Neurology 2015;epublished April 8th
- Abstract: Karsten. Positive end-expiratory pressure titration at bedside using electrical impedance tomography in post-operative cardiac surgery patients. Acta Anaesthesiologica Scandinavica 2015;epublished April 13th
- Campbell. Warming of intravenous and irrigation fluids for preventing inadvertent perioperative hypothermia. Cochrane Database of Systematic Reviews 2015, Issue 4. Art. No.: CD009891
- Navarro. Perioperative fluid theory: a statement from the international Fluid Optimization Group. Perioperative Medicine 2015;4:3
- Bajwa. Interdisciplinary position statement on management of hyperglycemia in peri-operative and intensive care. J Anaesthesiol Clin Pharmacol 2015;31:155-64
- Fonsmark. Danish national sedation strategy. Targeted therapy of discomfort associated with critical illness. Danish Society of Intensive Care Medicine (DSIT) and the Danish Society of Anesthesiology and Intensive Care Medicine (DASAIM). Dan Med J 2015;;61(4)
- Legrand. Biomarkers for AKI improve clinical practice: yes. Intensive Care Med 2015;41(4):615-617
- Ostermann. Biomarkers for AKI improve clinical practice: no. Intensive Care Med 2015;41(4):618-622
- Rangasami. Tracheostomy care in 2015: Are we on the right trach? JICS 2015;16(2):95-98
- Deane. Primum non nocere and challenging conventional treatment. Intensive Care Med 2015;epublished April 14th
- Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome. Lancet Respir Med 2015;3(4):e11–e12
- Individualised targeted haemodynamic therapy in high-risk surgical patients. Lancet Respir Med 2015;3(4):e13–e14
- Thompson. Evidence-Base for Fever Interventions Following Stroke. Stroke 2015;epublished April 14th
- Bakhsheshi. Non-invasive monitoring of brain temperature by near-infrared spectroscopy. Temperature 2015;31-32
- Adler. Fluid and electrolyte overload in critically ill patients: An overview. World J Crit Care Med 2015;4(2):116-129
- Sadera. Amniotic fluid embolism. J Obstet Anaesth Crit Care 2015;5:3-8
- Evora. Twenty years of vasoplegic syndrome treatment in heart surgery. Methylene blue revised. Paulo Roberto Barbosa. Rev Bras Cir Cardiovasc 2015;30(1):84–92
- Juarez. Acute exacerbation of idiopathic pulmonary fibrosis—a review of current and novel pharmacotherapies. J Thorac Dis 2015;7(3):499-519
- Lopez-Campos. Lights and shadows of non-invasive mechanical ventilation for chronic obstructive pulmonary disease (COPD) exacerbations. Ann Thorac Med 2015;10:87-93
- Leppert. Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction. Drug Design, Development and Therapy 2015;9:2215-2231
- Zhang. Biomarkers, diagnosis and management of sepsis-induced acute kidney injury: a narrative review. Heart Lung Vessel 2015;7(1):64–73
- Mirrakhimov. Tumor lysis syndrome: A clinical review. World J Crit Care Med 2015;4(2):130-138
- Emmi. Thrombosis in vasculitis: from pathogenesis to treatment. Thrombosis Journal 2015;13:15
- Martin-Loeches. Management of severe sepsis: advances, challenges, and current status. Drug Design, Development and Therapy 2015;9:2079-2088
- Allen. Anticoagulant modulation of inflammation in severe sepsis. World J Crit Care Med 4(2):105-115
- Vazquez-Grande. Optimizing Antimicrobial Therapy of Sepsis and Septic Shock. Focus on Antibiotic Combination Therapy. Semin Respir Crit Care Med 2015;36(1):154-166 (via Medscape)
- Nnedu. Update on the emerging role of telavancin in hospital-acquired infections. Therapeutics and Clinical Risk Management 2015'11:065-610
- Abdallah. Perioperative chlorhexidine allergy: Is it serious? . J Anaesthesiol Clin Pharmacol 2015;31:152-4
- Erstad. Designing drug regimens for special intensive care unit populations. World J Crit Care Med 2015;4(2):139-151
- Shah. Pharmacokinetic considerations and dosing strategies of antibiotics in the critically ill patient. JICS 2015;16(2):147-153
- Engel. Drowning episodes: prevention and resuscitation tips. J Fam Pract 2015;64(2):E1-6
- Griffiths. Medico-legal issues for intensivists caring for children in a District General Hospital. JICS 2015;16(2):137-141
- Szawarski. Classic cases revisited: Mrs Janet Tracey, resuscitation and the importance of good communication. JICS 2015;16(2):142-146
- Wolfe. Statistical models for respiratory disease diagnosis and prognosis. Respirology 2015;20:541–547
- Mengual-Macenlle. Multivariate analysis in thoracic research. J Thorac Dis 2015;7(3):E2-E6
- Viti. A practical overview on probability distributions. J Thorac Dis 2015;7(3):E7-E10
- Gust. The use of correlation functions in thoracic surgery research. J Thorac Dis 2015;7(3):E11-E15
Critical Care Horizons is a fresh new voice in the critical care literature, offering thought-provoking, cutting-edge commentary and opinion papers, plus state-of-the-art review articles. The journal is free to publish with and free to read, opening authorship opportunity to all. The energetic editorial board consists of a deliberate mix of clinicians active in social media and world renowned academics, all driven by a desire to improve the care we offer our patients, and operate without financial gain or incentive. A call for papers has been issued, so if you have something interesting to say, and can say it in an engaging manner, please get in touch.
COI - I am the editor-in-chief of this new journal, but work in a voluntary capacity, as do all the editors.
I hope you find these links useful.
Until next week