Royal College of Anaesthetists ICM Update Day

Management of ARDS

October 2nd 2015

 

Definitions

Chest Radiograph

  1. Rubenfeld. Interobserver variability in applying a radiographic definition for ARDS. Chest 1999;116:1347-1353
  2. Meade. Interobserver variation in interpreting chest radiographs for the diagnosis of acute respiratory distress syndrome. Am J Respir Crit Care Med 2000; 161:85–90
  3. Figueroa-Casas. Accuracy of the chest radiograph to identify bilateral pulmonary infiltrates consistent with the diagnosis of acute respiratory distress syndrome using computed tomography as reference standard. Journal of Critical Care 2013;28(4):352-357
  4. Aberle. Hydrostatic versus increased permeability pulmonary edema: diagnosis based on radiographic criteria in critically ill patients. Radiology 1988;168:73–79

Timing

  1. Villar. An early PEEP/FIO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 2007;176:795-804

Clinical Reality

  1. Rubenfeld. Interobserver variability in applying a radiographic definition for ARDS. Chest 1999;116:1347-1353

Recognition

  1. Ferguson. Acute respiratory distress syndrome: Underrecognition by clinicians and diagnostic accuracy of three clinical definitions. Critical Care Med 2005;33(10):2228-2234

Mortality Causes

  1. Stapleton. Causes and timing of death in patients with ARDS. Chest 2005;128:525-532

Mortality Prediction

  1. The ARDS Definition Task Force. Acute Respiratory Distress Syndrome. The Berlin Definition. JAMA 2012;307(23):2526-2533

Autopsy Studies

  1. Thille. Comparison of the Berlin Definition for Acute Respiratory Distress Syndrome with Autopsy. Am J Respir Crit Care 2013;187(7):761-767
  2. Esteban. Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings. Ann Intern Med 2004;141:440-445
  3. de Hemptinne. A Clinicopathological Confrontation. Chest 2009;135(4):944-949

Therapy

Tidal Volume

  1. Villar. The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med 2011; epub ahead of print.    (Erratum)
  2. Terragni. Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 2007;175:160–166
  3. Villar. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial (AIRES Study). Crit Care Med 2006; 34:1311-1318
  4. The Acute Respiratory Distress Syndrome Network. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. N Engl J Med 2000; 342:1301-1308
  5. Brower. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 1999;27:1492-1498
  6. Stewart. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group. N Engl J Med 1998;338:355-361.
  7. Amato. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998; 338:347-354.
  8. Brochard. Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trial Group on Tidal Volume Reduction in ARDS. Am J Respir Crit Care Med 1998; 158:1831-1838.
Prevention
  1. Determann. Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Crit Care. 2010;14(1):R1.
  2. Wolthuis. Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology 2008 Jan;108(1):46-54.

Driving Pressure

  1. Amato. Driving Pressure and Survival in the Acute Respiratory Distress Syndrome. N Engl J Med 2015; 372:747-755

PEEP

  1. Mercat. Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome. JAMA. 2008;299(6):646-655.
  2. Meade. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: A randomized controlled trial. JAMA 2008; 299:637-645.
  3. The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome. N Engl J Med 2004;351:327-36

Optimal Ventilation

  1. Putensen. Meta-analysis: Ventilation Strategies and Outcomes of the Acute Respiratory Distress Syndrome and Acute Lung Injury. Ann Intern Med. 2009;151:566-57  

Recruitment

  1. Fan. Recruitment Maneuvers for Acute Lung Injury: A Systematic Review. Am J Respir Crit Care Med 2008;178:1156–1163
  2. Gattinoni. Lung Recruitment in Patients with the Acute Respiratory Distress Syndrome. N Engl J Med 2006;354:1775-86.
  3. Povoa. Evaluation of a recruitment maneuver with positive inspiratory pressure and high PEEP in patients with severe ARDS. Acta Anaesthesiol Scand 2004;48:287-293.
  4. Brower. Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Crit Care Med 2003;31:2592-2597
  5. Halter. Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment. Am J Respir Crit Care Med 2003;167:1620-1626   (Video)
  6. Villagra. Recruitment maneuvers during lung protective ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 2002;165:165-170.

Modes of Ventilation

Inverse Ratio
  1. Morris.. Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome. Am J Respir Crit Care Med 1994;149(2):295-305

Neuromuscular Blockade in ARDS

  1. Papazian. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 2010;363:1107-1116  

Statins

  1. McAuley. Simvastatin in ARDS. New Engl J Med 2014;epublished September 30th
  2. The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome (SAILS). New Engl J Med 2014;epublished May 18th

Nitric Oxide

  1. Adhikari. Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ 2007; 334 : 779

Beta 2 Agonists

  1. Smith. Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial. Lancet epub ahead of print December 12 2011  (full text version)
  2. NHLBI ARDSnet. Randomized, Placebo-controlled Clinical Trial of an Aerosolized ?2-Agonist for Treatment of Acute Lung Injury. Am J Resp Crit Care Med 2011;184:561-568  (CAT Review - JICS 2012)   (Critique - Critical Care 2012)
  3. Perkins. The Beta-Agonist Lung Injury Trial (BALTI): A Randomized Placebo-controlled Clinical Trial.  Am J Respir Crit Care Med 2006;173:281–287

Corticosteroids

  1. Meduri. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 2007; 131:954-63.
  2. Steinberg. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006; 354:1671-84.  

Activated Protein C

  1. Cornet. Recombinant human activated protein C in the treatment of acute respiratory distress syndrome: a randomized clinical trial. PLoS One 2014;14;9(3):e90983
  2. Liu. Randomized Clinical Trial of Activated Protein C for the Treatment of Acute Lung Injury. Am J Respir Crit Care Med 2008;178(6):618-623

Surfactant

  1. Willson. The Adult Calfactant in Acute Respiratory Distress Syndrome (CARDS) Trial. Chest 2015;epublished April 9th
  2. Spragg. Recombinant Surfactant Protein C–based Surfactant for Patients with Severe Direct Lung Injury. American Journal of Respiratory and Critical Care Medicine 2011;183(8):1055 –1061
  3. Kesecioglu. Exogenous Natural Surfactant for Treatment of Acute Lung Injury and the Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2009;180(10):989–994
  4. Spragg. Effect of Recombinant Surfactant Protein C–Based Surfactant on the Acute Respiratory Distress Syndrome. N Engl J Med 2004;351(9):884–92
  5. Spragg. Treatment of Acute Respiratory Distress Syndrome with Recombinant Surfactant Protein C Surfactant. Am J Respir Crit Care Med 2003;167(11):1562–6
  6. Anzueto. Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group. N Engl J Med 1996;334:1417–1421

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